1ZRB
Thrombin in complex with an azafluorenyl inhibitor 23b
Summary for 1ZRB
Entry DOI | 10.2210/pdb1zrb/pdb |
Descriptor | thrombin, 11-peptide hirudin fragment, 3-AZA-9-HYDROXY-9-FLUORENYLCARBONYL-L-PROLYL-2-AMINOMETHYL-5-CHLOROBENZYLAMIDE, N-OXIDE, ... (4 entities in total) |
Functional Keywords | thrombin; thrombin inhibitor complex, blood clotting, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 Secreted: P28504 |
Total number of polymer chains | 2 |
Total formula weight | 35064.45 |
Authors | Stauffer, K.J.,Williams, P.D.,Selnick, H.G.,Nantermet, P.G.,Newton, C.L.,Homnick, C.F.,Zrada, M.M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Pietrak, B.L.,Lyle, E.A.,Singh, R.,Miller-Stein, C.,White, R.B.,Wong, B.,Wallace, A.A.,Sitko, G.R.,Cook, J.J.,Holahan, M.A.,Stranieri-Michener, M.,Leonard, Y.M.,Lynch Jr., J.J.,McMasters, D.R.,Yan, Y. (deposition date: 2005-05-19, release date: 2005-06-07, Last modification date: 2013-03-13) |
Primary citation | Stauffer, K.J.,Williams, P.D.,Selnick, H.G.,Nantermet, P.G.,Newton, C.L.,Homnick, C.F.,Zrada, M.M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Pietrak, B.L.,Lyle, E.A.,Singh, R.,Miller-Stein, C.,White, R.B.,Wong, B.,Wallace, A.A.,Sitko, G.R.,Cook, J.J.,Holahan, M.A.,Stranieri-Michener, M.,Leonard, Y.M.,Lynch Jr., J.J.,McMasters, D.R.,Yan, Y. 9-hydroxyazafluorenes and their use in thrombin inhibitors J.Med.Chem., 48:2282-2293, 2005 Cited by PubMed: 15801822DOI: 10.1021/jm049423s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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