1Z6E
Factor XA in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol-5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; DPC906; BMS-561389)
Summary for 1Z6E
Entry DOI | 10.2210/pdb1z6e/pdb |
Descriptor | Coagulation factor X, 1-(3-AMINO-1,2-BENZISOXAZOL-5-YL)-N-(4-{2-[(DIMETHYLAMINO)METHYL]-1H-IMIDAZOL-1-YL}-2-FLUOROPHENYL)-3-(TRIFLUOROMETHYL) -1H-PYRAZOLE-5-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, blood coagulation, cleavage on pair of basic residues, disulfide bond, egf-like domain |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 2 |
Total formula weight | 32564.80 |
Authors | Alexander, R.S. (deposition date: 2005-03-22, release date: 2006-03-28, Last modification date: 2023-08-23) |
Primary citation | Quan, M.L.,Lam, P.Y.S.,Han, Q.,Pinto, D.J.P.,He, M.Y.,Li, R.,Ellis, C.D.,Clark, C.G.,Teleha, C.A.,Sun, J.-H.,Alexander, R.S.,Bai, S.,Luettgen, J.M.,Knabb, R.M.,Wong, P.C.,Wexler, R.R. Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor. J.Med.Chem., 48:1729-1744, 2005 Cited by PubMed: 15771420DOI: 10.1021/jm0497949 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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