1Z62

Indirubin-3'-aminooxy-acetate inhibits glycogen phosphorylase by binding at the inhibitor and the allosteric site. Broad specificities of the two sites

Summary for 1Z62

• Entry DOI: 10.2210/pdb1z62/pdb
• Related: 2AMV
• Descriptor: Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ({[(3E)-2'-OXO-2',7'-DIHYDRO-2,3'-BIINDOL-3(7H)-YLIDENE]AMINO}OXY)ACETIC ACID, ... (4 entities in total)
• Functional Keywords: glycogenolysis, type 2 diabetes, transferase
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 98544.29

Authors

Kosmopoulou, M.N.,Leonidas, D.D.,Chrysina, E.D.,Eisenbrand, G.,Oikonomakos, N.G. (deposition date: 2005-03-21, release date: 2006-03-07, Last modification date: 2025-03-26)

• Primary citation: Kosmopoulou, M.N.,Leonidas, D.D.,Chrysina, E.D.,Eisenbrand, G.,Oikonomakos, N.G.; Indirubin-3'-Aminooxy-Acetate Inhibits Glycogen Phosphorylase by Binding at the Inhibitor and the Allosteric Site. Broad Specificities of the Two Sites; LETT.DRUG DES.DISCOVERY, 2:377-390, 2005

Experimental method

X-RAY DIFFRACTION (1.9 Å)