1YVF
Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145
Summary for 1YVF
Entry DOI | 10.2210/pdb1yvf/pdb |
Descriptor | HCV NS5B POLYMERASE, PHOSPHATE ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | ns5b, polymerase, hcv, fingers, palm, thumb, transferase |
Biological source | Hepatitis C virus |
Total number of polymer chains | 1 |
Total formula weight | 65319.13 |
Authors | Pfefferkorn, J.A.,Greene, M.L.,Nugent, R.A.,Gross, R.J.,Mitchell, M.A.,Finzel, B.C.,Harris, M.S.,Wells, P.A.,Shelly, J.A.,Anstadt, R.A.,Kilkuskie, R.E.,Kopta, L.A.,Schwende, F.J. (deposition date: 2005-02-15, release date: 2005-04-19, Last modification date: 2024-02-14) |
Primary citation | Pfefferkorn, J.A.,Greene, M.L.,Nugent, R.A.,Gross, R.J.,Mitchell, M.A.,Finzel, B.C.,Harris, M.S.,Wells, P.A.,Shelly, J.A.,Anstadt, R.A.,Kilkuskie, R.E.,Kopta, L.A.,Schwende, F.J. Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid. Bioorg.Med.Chem.Lett., 15:2481-2486, 2005 Cited by PubMed: 15863301DOI: 10.1016/j.bmcl.2005.03.066 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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