1YOM

Crystal structure of Src kinase domain in complex with Purvalanol A

Summary for 1YOM

Entry DOI	10.2210/pdb1yom/pdb
Related	1YOJ 1YOL
Descriptor	Proto-oncogene tyrosine-protein kinase Src, 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL (3 entities in total)
Functional Keywords	protein tyrosine kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane: P12931
Total number of polymer chains	2
Total formula weight	65678.28
Authors	Breitenlechner, C.B.,Kairies, N.A.,Honold, K.,Scheiblich, S.,Koll, H.,Greiter, E.,Koch, S.,Schaefer, W.,Huber, R.,Engh, R.A. (deposition date: 2005-01-27, release date: 2006-01-27, Last modification date: 2021-11-10)
Primary citation	Breitenlechner, C.B.,Kairies, N.A.,Honold, K.,Scheiblich, S.,Koll, H.,Greiter, E.,Koch, S.,Schaefer, W.,Huber, R.,Engh, R.A. Crystal structures of active SRC kinase domain complexes J.Mol.Biol., 353:222-231, 2005 Cited by PubMed: 16168436 DOI: 10.1016/j.jmb.2005.08.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation