1YOM
Crystal structure of Src kinase domain in complex with Purvalanol A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 283 | 32450.2 | 2 | UniProt (P12931) Pfam (PF07714) | Homo sapiens (human) | p60-SRC, C-SRC |
| 2 | C, D (A, B) | 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL | non-polymer | 388.9 | 2 | Chemie (P01) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
A, B: 253 - 535 (UniProt: P12931)
| PDB | External Database | Details |
|---|---|---|
| Asn 344 | Ser 344 | engineered mutation |
| Ser 369 | Ala 369 | engineered mutation |
| Trp 418 | Tyr 418 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64900.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 777.8 | |
| All* | Total formula weight | 65678.3 |
