1YOL

Crystal structure of Src kinase domain in complex with CGP77675

Summary for 1YOL

Entry DOI	10.2210/pdb1yol/pdb
Related	1YOJ 1YOM
Descriptor	Proto-oncogene tyrosine-protein kinase Src, 1-{4-[4-AMINO-5-(3-METHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL]BENZYL}PIPERIDIN-4-OL (3 entities in total)
Functional Keywords	protein tyrosine kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane: P12931
Total number of polymer chains	2
Total formula weight	65713.45
Authors	Breitenlechner, C.B.,Kairies, N.A.,Honold, K.,Scheiblich, S.,Koll, H.,Greiter, E.,Koch, S.,Schaefer, W.,Huber, R.,Engh, R.A. (deposition date: 2005-01-27, release date: 2006-01-27, Last modification date: 2023-10-25)
Primary citation	Breitenlechner, C.B.,Kairies, N.A.,Honold, K.,Scheiblich, S.,Koll, H.,Greiter, E.,Koch, S.,Schaefer, W.,Huber, R.,Engh, R.A. Crystal structures of active SRC kinase domain complexes J.Mol.Biol., 353:222-231, 2005 Cited by PubMed: 16168436 DOI: 10.1016/j.jmb.2005.08.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation