1U7V

Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex

Summary for 1U7V

• Entry DOI: 10.2210/pdb1u7v/pdb
• Related: 1U7F
• Descriptor: Mothers against decapentaplegic homolog 2, Mothers against decapentaplegic homolog 4 (2 entities in total)
• Functional Keywords: smad, tgf-beta, signal transduction, protein complex, phosphorylation, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q15796 Q13485
• Total number of polymer chains: 3
• Total formula weight: 70734.00

Authors

Chacko, B.M.,Qin, B.Y.,Tiwari, A.,Shi, G.,Lam, S.,Hayward, L.J.,de Caestecker, M.,Lin, K. (deposition date: 2004-08-04, release date: 2004-09-28, Last modification date: 2023-08-23)

• Primary citation: Chacko, B.M.,Qin, B.Y.,Tiwari, A.,Shi, G.,Lam, S.,Hayward, L.J.,De Caestecker, M.,Lin, K.; Structural basis of heteromeric smad protein assembly in tgf-Beta signaling; Mol.Cell, 15:813-823, 2004; PubMed: 15350224; DOI: 10.1016/j.molcel.2004.07.016

Experimental method

X-RAY DIFFRACTION (2.7 Å)