1TXI
Crystal structure of the vdr ligand binding domain complexed to TX522
Summary for 1TXI
Entry DOI | 10.2210/pdb1txi/pdb |
Related | 1DB1 1IE8 1IE9 1S19 1SOZ |
Descriptor | Vitamin D receptor, (1R,3R)-5-((Z)-2-((1R,7AS)-HEXAHYDRO-1-((S)-6-HYDROXY-6-METHYLHEPT-4-YN-2-YL)-7A-METHYL-1H-INDEN-4(7AH)-YLIDENE)ETHYLIDENE)CYCLOHEXANE-1,3-DIOL (3 entities in total) |
Functional Keywords | vdr ligand binding domain, tx522 complex, nuclear receptor, transcription regulation, alpha-helical sandwich, gene regulation |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 30205.94 |
Authors | Moras, D.,Rochel, N. (deposition date: 2004-07-05, release date: 2005-05-10, Last modification date: 2024-03-13) |
Primary citation | Eelen, G.,Verlinden, L.,Rochel, N.,Claessens, F.,De Clercq, P.,Vandewalle, M.,Tocchini-Valentini, G.,Moras, D.,Bouillon, R.,Verstuyf, A. Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction Mol.Pharmacol., 67:1566-1573, 2005 Cited by PubMed: 15728261DOI: 10.1124/mol.104.008730 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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