1TVE

Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol

Summary for 1TVE

Entry DOI	10.2210/pdb1tve/pdb
Related	1EBF 1EBU 1Q7G
Descriptor	Homoserine dehydrogenase, 4-(4-HYDROXY-3-ISOPROPYLPHENYLTHIO)-2-ISOPROPYLPHENOL (2 entities in total)
Functional Keywords	antifungal; small molecule screening; amino acid biosynthesis, oxidoreductase
Biological source	Saccharomyces cerevisiae (baker's yeast)
Total number of polymer chains	2
Total formula weight	77432.39
Authors	Ejim, L.,Mirza, I.A.,Capone, C.,Nazi, I.,Jenkins, S.,Chee, G.L.,Berghuis, A.M.,Wright, G.D. (deposition date: 2004-06-29, release date: 2004-07-13, Last modification date: 2023-08-23)
Primary citation	Ejim, L.,Mirza, I.A.,Capone, C.,Nazi, I.,Jenkins, S.,Chee, G.L.,Berghuis, A.M.,Wright, G.D. New phenolic inhibitors of yeast homoserine dehydrogenase Bioorg.Med.Chem., 12:3825-3830, 2004 Cited by PubMed: 15210149 DOI: 10.1016/j.bmc.2004.05.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation