1R64
The 2.2 A crystal structure of Kex2 protease in complex with Ac-Arg-Glu-Lys-boroArg peptidyl boronic acid inhibitor
Summary for 1R64
Entry DOI | 10.2210/pdb1r64/pdb |
Related PRD ID | PRD_000420 |
Descriptor | Kexin, Ac-Arg-Glu-Lys-boroArg peptide inhibitor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | kex2, kexin, protease, protein convertase, prohormone processing, proprotein convertase, subtilisin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (baker's yeast) More |
Cellular location | Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P13134 |
Total number of polymer chains | 4 |
Total formula weight | 108707.82 |
Authors | Holyoak, T.,Kettner, C.A.,Petsko, G.A.,Fuller, R.S.,Ringe, D. (deposition date: 2003-10-14, release date: 2004-03-09, Last modification date: 2023-11-15) |
Primary citation | Holyoak, T.,Kettner, C.A.,Petsko, G.A.,Fuller, R.S.,Ringe, D. Structural Basis for Differences in Substrate Selectivity in Kex2 and Furin Protein Convertases Biochemistry, 43:2412-2421, 2004 Cited by PubMed: 14992578DOI: 10.1021/bi035849h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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