1QKI

X-RAY STRUCTURE OF HUMAN GLUCOSE 6-PHOSPHATE DEHYDROGENASE (VARIANT CANTON R459L) COMPLEXED WITH STRUCTURAL NADP+

Summary for 1QKI

• Entry DOI: 10.2210/pdb1qki/pdb
• Related: 1DPG 2DPG
• Descriptor: GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCOLIC ACID, ... (5 entities in total)
• Functional Keywords: oxidoreductase, oxidoredutase, (choh(d)-nadp), glucose metabolism
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 8
• Total formula weight: 480355.05

Authors

Au, S.W.N.,Gover, S.,Lam, V.M.S.,Adams, M.J. (deposition date: 1999-07-20, release date: 2000-03-16, Last modification date: 2023-12-13)

Primary citation

Au, S.W.N.,Gover, S.,Lam, V.M.S.,Adams, M.J.
Human Glucose-6-Phosphate Dehydrogenase: The Crystal Structure Reveals a Structural Nadp+ Molecule and Provides Insights Into Enzyme Deficiency
Structure, 8:293-, 2000

PubMed Abstract: Glucose-6-phosphate dehydrogenase (G6PD) catalyses the first committed step in the pentose phosphate pathway; the generation of NADPH by this enzyme is essential for protection against oxidative stress. The human enzyme is in a dimer<-->tetramer equilibrium and its stability is dependent on NADP(+) concentration. G6PD deficiency results from many different point mutations in the X-linked gene encoding G6PD and is the most common human enzymopathy. Severe deficiency causes chronic non-spherocytic haemolytic anaemia; the usual symptoms are neonatal jaundice, favism and haemolytic anaemia.

PubMed: 10745013
DOI: 10.1016/S0969-2126(00)00104-0

Experimental method

X-RAY DIFFRACTION (3 Å)