1PO2
POLIOVIRUS (TYPE 1, MAHONEY) IN COMPLEX WITH R77975, AN INHIBITOR OF VIRAL REPLICATION
Summary for 1PO2
Entry DOI | 10.2210/pdb1po2/pdb |
Descriptor | POLIOVIRUS TYPE 1 MAHONEY, (METHYLPYRIDAZINE PIPERIDINE ETHYLOXYPHENYL)ETHYLACETATE, MYRISTIC ACID, ... (7 entities in total) |
Functional Keywords | poliovirus, picornavirus coat protein, anti-viral drugs, hydrolase, thiol protease, icosahedral virus, virus |
Biological source | Human poliovirus 1 More |
Cellular location | Capsid protein VP0: Virion. Capsid protein VP4: Virion. Capsid protein VP2: Virion. Capsid protein VP3: Virion. Capsid protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion. Protease 3C: Host cytoplasm. Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03300 P03300 P03300 |
Total number of polymer chains | 5 |
Total formula weight | 98540.16 |
Authors | Hiremath, C.N.,Filman, D.J.,Grant, R.A.,Hogle, J.M. (deposition date: 1997-01-08, release date: 1997-12-03, Last modification date: 2023-08-09) |
Primary citation | Hiremath, C.N.,Filman, D.J.,Grant, R.A.,Hogle, J.M. Ligand-induced conformational changes in poliovirus-antiviral drug complexes. Acta Crystallogr.,Sect.D, 53:558-570, 1997 Cited by PubMed: 15299887DOI: 10.1107/S0907444997000954 PDB entries with the same primary citation |
Experimental method |
Structure validation
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