1NPW

Crystal structure of HIV protease complexed with LGZ479

Summary for 1NPW

Entry DOI	10.2210/pdb1npw/pdb
Related	1NPA 1NPV
Descriptor	POL polyprotein, CARBAMIC ACID 1-{5-BENZYL-5-[2-HYDROXY-4-PHENYL-3-(TETRAHYDRO-FURAN- 3-YLOXYCARBONYLAMINO)-BUTYL]-4-OXO-4,5-DIHYDRO-1H-PYRROL-3-YL}- INDAN-2-YL ESTER (3 entities in total)
Functional Keywords	protease, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22233.22
Authors	Smith III, A.B. (deposition date: 2003-01-20, release date: 2003-02-04, Last modification date: 2024-02-14)
Primary citation	Smith III, A.B.,Cantin, L.D.,Pasternak, A.,Guise-Zawacki, L.,Yao, W.,Charnley, A.K.,Barbosa, J.,Sprengeler, P.A.,Hirschmann, R.,Munshi, S.,Olsen, D.B.,Schleif, W.A.,Kuo, L.C. Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors. J.Med.Chem., 46:1831-1844, 2003 Cited by PubMed: 12723947 DOI: 10.1021/jm0204587 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation