1NPV
Crystal structure of HIV-1 protease complexed with LDC271
Summary for 1NPV
Entry DOI | 10.2210/pdb1npv/pdb |
Descriptor | POL polyprotein, {1-BENZYL-3-[2-BENZYL-3-OXO-4-(1-OXO-1,2,3,4-TETRAHYDRO- ISOQUINOLIN-4-YL)-2,3-DIHYDRO-1H-PYRROL-2-YL]-2- HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER (3 entities in total) |
Functional Keywords | protease, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22203.20 |
Authors | Smith, A.B. (deposition date: 2003-01-20, release date: 2003-02-04, Last modification date: 2024-02-14) |
Primary citation | Smith, A.B.,Cantin, L.D.,Pasternak, A.,Guise-Zawacki, L.,Yao, W.,Charnley, A.K.,Barbosa, J.,Sprengeler, P.A.,Hirschmann, R.,Munshi, S.,Olsen, D.B.,Schleif, W.A.,Kuo, L.C. Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors. J.Med.Chem., 46:1831-1844, 2003 Cited by PubMed: 12723947DOI: 10.1021/jm0204587 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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