1NC6
Potent, small molecule inhibitors of human mast cell tryptase. Anti-asthmatic action of a dipeptide-based transition state analogue containing benzothiazole ketone
Summary for 1NC6
Entry DOI | 10.2210/pdb1nc6/pdb |
Descriptor | Trypsinogen, CALCIUM ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | protein-inhibitor complex, hydrolase |
Biological source | Bos taurus (cattle) |
Cellular location | Secreted, extracellular space: P00760 |
Total number of polymer chains | 1 |
Total formula weight | 23906.95 |
Authors | Costanzo, M.J.,Yabut, S.C.,Almond Jr., H.R.,Andrade-Gordon, P.,Corcoran, T.W.,de Garavilla, L.,Kauffman, J.A.,Abraham, W.M.,Recacha, R.,Chattopadhyay, D.,Maryanoff, B.E. (deposition date: 2002-12-04, release date: 2003-09-23, Last modification date: 2017-10-11) |
Primary citation | Costanzo, M.J.,Yabut, S.C.,Almond Jr., H.R.,Andrade-Gordon, P.,Corcoran, T.W.,De Garavilla, L.,Kauffman, J.A.,Abraham, W.M.,Recacha, R.,Chattopadhyay, D.,Maryanoff, B.E. Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone. J.Med.Chem., 46:3865-3876, 2003 Cited by PubMed: 12930148DOI: 10.1021/jm030050p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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