1ML3
Evidences for a flip-flop catalytic mechanism of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, from its crystal structure in complex with reacted irreversible inhibitor 2-(2-phosphono-ethyl)-acrylic acid 4-nitro-phenyl ester
Summary for 1ML3
Entry DOI | 10.2210/pdb1ml3/pdb |
Related | 1A7K 1GYP |
Descriptor | Glyceraldehyde 3-phosphate dehydrogenase, glycosomal, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (3-FORMYL-BUT-3-ENYL)-PHOSPHONIC ACID, ... (4 entities in total) |
Functional Keywords | protein covalent-inhibitor complex, oxidoreductase |
Biological source | Trypanosoma cruzi |
Cellular location | Glycosome: P22513 |
Total number of polymer chains | 4 |
Total formula weight | 158932.72 |
Authors | Castilho, M.S.,Pavao, F.,Oliva, G. (deposition date: 2002-08-29, release date: 2003-07-08, Last modification date: 2024-10-16) |
Primary citation | Castilho, M.S.,Pavao, F.,Oliva, G.,Ladame, S.,Willson, M.,Perie, J. Evidence for the Two Phosphate Binding Sites of an Analogue of the Thioacyl Intermediate for the Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase-Catalyzed Reaction, from Its Crystal Structure. Biochemistry, 42:7143-7151, 2003 Cited by PubMed: 12795610DOI: 10.1021/bi0206107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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