1M52
Crystal Structure of the c-Abl Kinase domain in complex with PD173955
Summary for 1M52
Entry DOI | 10.2210/pdb1m52/pdb |
Related | 1IEP |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1, 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | kinase, kinase inhibitor, pd173955, activation loop, transferase |
Biological source | Mus musculus (house mouse) |
Cellular location | Cytoplasm, cytoskeleton: P00520 |
Total number of polymer chains | 2 |
Total formula weight | 68764.22 |
Authors | Nagar, B.,Bornmann, W.,Pellicena, P.,Schindler, T.,Veach, D.,Miller, W.T.,Clarkson, B.,Kuriyan, J. (deposition date: 2002-07-08, release date: 2002-09-18, Last modification date: 2024-02-14) |
Primary citation | Nagar, B.,Bornmann, W.,Pellicena, P.,Schindler, T.,Veach, D.,Miller, W.T.,Clarkson, B.,Kuriyan, J. Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571) Cancer Res., 62:4236-4243, 2002 Cited by PubMed: 12154025PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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