1M52
Crystal Structure of the c-Abl Kinase domain in complex with PD173955
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 | polymer | 293 | 33743.5 | 2 | UniProt (P00520) Pfam (PF07714) | Mus musculus (house mouse) | p150, c-ABL |
| 2 | C, F (A, B) | 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE | non-polymer | 443.3 | 2 | Chemie (P17) | |||
| 3 | D, E (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A, B: 229 - 515 (UniProt: P00520)
| PDB | External Database | Details |
|---|---|---|
| Gly 223 | - | cloning artifact |
| Ala 224 | - | cloning artifact |
| Met 225 | - | cloning artifact |
| Asp 226 | - | cloning artifact |
| Pro 227 | - | cloning artifact |
| Ser 228 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67487.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1277.2 | |
| All* | Total formula weight | 68764.2 |
