1M52
Crystal Structure of the c-Abl Kinase domain in complex with PD173955
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 | polymer | 293 | 33743.5 | 2 | UniProt (P00520) Pfam (PF07714) In PDB | Mus musculus (house mouse) | p150, c-ABL |
2 | A, B | 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE | non-polymer | 443.3 | 2 | Chemie (P17) | |||
3 | B | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
4 | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A, B: 229 - 515 (UniProt: P00520)
PDB | External Database | Details |
---|---|---|
Gly 223 | - | cloning artifact |
Ala 224 | - | cloning artifact |
Met 225 | - | cloning artifact |
Asp 226 | - | cloning artifact |
Pro 227 | - | cloning artifact |
Ser 228 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 67487.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1277.2 | |
All* | Total formula weight | 68764.2 |