1JR1

Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid

Summary for 1JR1

Entry DOI	10.2210/pdb1jr1/pdb
Related	1AK5 1B3O 1ZFJ
Descriptor	Inosine-5'-Monophosphate Dehydrogenase 2, POTASSIUM ION, INOSINIC ACID, ... (5 entities in total)
Functional Keywords	dehydrogenase, impd, impdh, guanine nucleotide synthesis, mycophenolic acid, mpa, oxidoreductase
Biological source	Cricetulus griseus (Chinese hamster)
Cellular location	Cytoplasm : P12269
Total number of polymer chains	2
Total formula weight	113337.45
Authors	Sintchak, M.D.,Fleming, M.A.,Futer, O.,Raybuck, S.A.,Chambers, S.P.,Caron, P.R.,Murcko, M.A.,Wilson, K.P. (deposition date: 2001-08-09, release date: 2001-09-05, Last modification date: 2017-10-04)
Primary citation	Sintchak, M.D.,Fleming, M.A.,Futer, O.,Raybuck, S.A.,Chambers, S.P.,Caron, P.R.,Murcko, M.A.,Wilson, K.P. Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Cell(Cambridge,Mass.), 85:921-930, 1996 Cited by PubMed: 8681386 DOI: 10.1016/S0092-8674(00)81275-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation