1JJ9
Crystal Structure of MMP8-Barbiturate Complex Reveals Mechanism for Collagen Substrate Recognition
Summary for 1JJ9
Entry DOI | 10.2210/pdb1jj9/pdb |
Descriptor | Matrix Metalloproteinase 8, CALCIUM ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | mmp-8, substrate recognition, cis-peptide bond, conformational transition, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasmic granule: P22894 |
Total number of polymer chains | 1 |
Total formula weight | 18654.08 |
Authors | Brandstetter, H.,Grams, F.,Glitz, D.,Lang, A.,Huber, R.,Bode, W.,Krell, H.-W.,Engh, R.A. (deposition date: 2001-07-04, release date: 2001-08-01, Last modification date: 2024-03-13) |
Primary citation | Brandstetter, H.,Grams, F.,Glitz, D.,Lang, A.,Huber, R.,Bode, W.,Krell, H.W.,Engh, R.A. The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition. J.Biol.Chem., 276:17405-17412, 2001 Cited by PubMed: 11278347DOI: 10.1074/jbc.M007475200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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