1HE1

Crystal structure of the complex between the GAP domain of the Pseudomonas aeruginosa ExoS toxin and human Rac

Summary for 1HE1

Entry DOI	10.2210/pdb1he1/pdb
Related	1E96 1HE9 1MH1
NMR Information	BMRB: 5511
Descriptor	EXOENZYME S, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1, NICKEL (II) ION, ... (7 entities in total)
Functional Keywords	signaling protein, signalling complex, exos, rac, pseudomonas aeruginosa, gap, toxin, virulence factor, transition state, protein-protein complex, gtpase, signal transduction
Biological source	PSEUDOMONAS AERUGINOSA More
Cellular location	Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P15154
Total number of polymer chains	4
Total formula weight	68987.09
Authors	Wurtele, M.,Wolf, E.,Pederson, K.J.,Buchwald, G.,Ahmadian, M.R.,Barbieri, J.T.,Wittinghofer, A. (deposition date: 2000-11-18, release date: 2001-01-02, Last modification date: 2023-12-13)
Primary citation	Wurtele, M.,Wolf, E.,Pederson, K.J.,Buchwald, G.,Ahmadian, M.R.,Barbieri, J.T.,Wittinghofer, A. How the Pseudomonas Aeruginosa Exos Toxin Downregulates Rac Nat.Struct.Biol., 8:23-, 2001 Cited by PubMed: 11135665 DOI: 10.1038/83007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation