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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1HE1

Crystal structure of the complex between the GAP domain of the Pseudomonas aeruginosa ExoS toxin and human Rac

Functional Information from GO Data
ChainGOidnamespacecontents
A0005096molecular_functionGTPase activator activity
B0005096molecular_functionGTPase activator activity
C0000166molecular_functionnucleotide binding
C0000242cellular_componentpericentriolar material
C0001764biological_processneuron migration
C0001891cellular_componentphagocytic cup
C0001934biological_processpositive regulation of protein phosphorylation
C0002093biological_processauditory receptor cell morphogenesis
C0003376biological_processsphingosine-1-phosphate receptor signaling pathway
C0003382biological_processepithelial cell morphogenesis
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005789cellular_componentendoplasmic reticulum membrane
C0005802cellular_componenttrans-Golgi network
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006897biological_processendocytosis
C0006911biological_processphagocytosis, engulfment
C0006954biological_processinflammatory response
C0006972biological_processhyperosmotic response
C0007010biological_processcytoskeleton organization
C0007015biological_processactin filament organization
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007163biological_processestablishment or maintenance of cell polarity
C0007167biological_processenzyme-linked receptor protein signaling pathway
C0007186biological_processG protein-coupled receptor signaling pathway
C0007264biological_processsmall GTPase-mediated signal transduction
C0007411biological_processaxon guidance
C0008045biological_processmotor neuron axon guidance
C0008360biological_processregulation of cell shape
C0009611biological_processresponse to wounding
C0009653biological_processanatomical structure morphogenesis
C0010310biological_processregulation of hydrogen peroxide metabolic process
C0010591biological_processregulation of lamellipodium assembly
C0010592biological_processpositive regulation of lamellipodium assembly
C0010595biological_processpositive regulation of endothelial cell migration
C0010762biological_processregulation of fibroblast migration
C0010764biological_processnegative regulation of fibroblast migration
C0010810biological_processregulation of cell-substrate adhesion
C0010811biological_processpositive regulation of cell-substrate adhesion
C0014041biological_processregulation of neuron maturation
C0016020cellular_componentmembrane
C0016358biological_processdendrite development
C0016477biological_processcell migration
C0016601biological_processRac protein signal transduction
C0016787molecular_functionhydrolase activity
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0021799biological_processcerebral cortex radially oriented cell migration
C0021831biological_processembryonic olfactory bulb interneuron precursor migration
C0021894biological_processcerebral cortex GABAergic interneuron development
C0022604biological_processregulation of cell morphogenesis
C0030027cellular_componentlamellipodium
C0030031biological_processcell projection assembly
C0030032biological_processlamellipodium assembly
C0030036biological_processactin cytoskeleton organization
C0030041biological_processactin filament polymerization
C0030334biological_processregulation of cell migration
C0030425cellular_componentdendrite
C0030667cellular_componentsecretory granule membrane
C0030672cellular_componentsynaptic vesicle membrane
C0030742molecular_functionGTP-dependent protein binding
C0030838biological_processpositive regulation of actin filament polymerization
C0030865biological_processcortical cytoskeleton organization
C0030900biological_processforebrain development
C0031116biological_processpositive regulation of microtubule polymerization
C0031410cellular_componentcytoplasmic vesicle
C0031529biological_processruffle organization
C0031901cellular_componentearly endosome membrane
C0031996molecular_functionthioesterase binding
C0032496biological_processresponse to lipopolysaccharide
C0032587cellular_componentruffle membrane
C0032707biological_processnegative regulation of interleukin-23 production
C0032956biological_processregulation of actin cytoskeleton organization
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035025biological_processpositive regulation of Rho protein signal transduction
C0035556biological_processintracellular signal transduction
C0035567biological_processnon-canonical Wnt signaling pathway
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0042470cellular_componentmelanosome
C0042554biological_processsuperoxide anion generation
C0042734cellular_componentpresynaptic membrane
C0042995cellular_componentcell projection
C0043020cellular_componentNADPH oxidase complex
C0043131biological_processerythrocyte enucleation
C0043652biological_processengulfment of apoptotic cell
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0045216biological_processcell-cell junction organization
C0045428biological_processregulation of nitric oxide biosynthetic process
C0045730biological_processrespiratory burst
C0046425biological_processregulation of receptor signaling pathway via JAK-STAT
C0048012biological_processhepatocyte growth factor receptor signaling pathway
C0048168biological_processregulation of neuronal synaptic plasticity
C0048261biological_processnegative regulation of receptor-mediated endocytosis
C0048532biological_processanatomical structure arrangement
C0048812biological_processneuron projection morphogenesis
C0048813biological_processdendrite morphogenesis
C0048870biological_processcell motility
C0048873biological_processhomeostasis of number of cells within a tissue
C0051022molecular_functionRho GDP-dissociation inhibitor binding
C0051492biological_processregulation of stress fiber assembly
C0051496biological_processpositive regulation of stress fiber assembly
C0051668biological_processlocalization within membrane
C0051894biological_processpositive regulation of focal adhesion assembly
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051932biological_processsynaptic transmission, GABAergic
C0055038cellular_componentrecycling endosome membrane
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060091cellular_componentkinocilium
C0060263biological_processregulation of respiratory burst
C0060326biological_processcell chemotaxis
C0060999biological_processpositive regulation of dendritic spine development
C0061344biological_processregulation of cell adhesion involved in heart morphogenesis
C0070062cellular_componentextracellular exosome
C0070376biological_processregulation of ERK5 cascade
C0071526biological_processsemaphorin-plexin signaling pathway
C0071542biological_processdopaminergic neuron differentiation
C0072659biological_processprotein localization to plasma membrane
C0086098biological_processangiotensin-activated signaling pathway involved in heart process
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0090103biological_processcochlea morphogenesis
C0097178biological_processruffle assembly
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0101003cellular_componentficolin-1-rich granule membrane
C0150052biological_processregulation of postsynapse assembly
C1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
C1900029biological_processpositive regulation of ruffle assembly
C1900242biological_processregulation of synaptic vesicle endocytosis
C1902622biological_processregulation of neutrophil migration
C1903348biological_processpositive regulation of bicellular tight junction assembly
C1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
C1904936biological_processinterneuron migration
C1904948biological_processmidbrain dopaminergic neuron differentiation
C2000386biological_processpositive regulation of ovarian follicle development
C2001222biological_processregulation of neuron migration
D0000166molecular_functionnucleotide binding
D0000242cellular_componentpericentriolar material
D0001764biological_processneuron migration
D0001891cellular_componentphagocytic cup
D0001934biological_processpositive regulation of protein phosphorylation
D0002093biological_processauditory receptor cell morphogenesis
D0003376biological_processsphingosine-1-phosphate receptor signaling pathway
D0003382biological_processepithelial cell morphogenesis
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005789cellular_componentendoplasmic reticulum membrane
D0005802cellular_componenttrans-Golgi network
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005884cellular_componentactin filament
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0005938cellular_componentcell cortex
D0006897biological_processendocytosis
D0006911biological_processphagocytosis, engulfment
D0006954biological_processinflammatory response
D0006972biological_processhyperosmotic response
D0007010biological_processcytoskeleton organization
D0007015biological_processactin filament organization
D0007155biological_processcell adhesion
D0007160biological_processcell-matrix adhesion
D0007163biological_processestablishment or maintenance of cell polarity
D0007167biological_processenzyme-linked receptor protein signaling pathway
D0007186biological_processG protein-coupled receptor signaling pathway
D0007264biological_processsmall GTPase-mediated signal transduction
D0007411biological_processaxon guidance
D0008045biological_processmotor neuron axon guidance
D0008360biological_processregulation of cell shape
D0009611biological_processresponse to wounding
D0009653biological_processanatomical structure morphogenesis
D0010310biological_processregulation of hydrogen peroxide metabolic process
D0010591biological_processregulation of lamellipodium assembly
D0010592biological_processpositive regulation of lamellipodium assembly
D0010595biological_processpositive regulation of endothelial cell migration
D0010762biological_processregulation of fibroblast migration
D0010764biological_processnegative regulation of fibroblast migration
D0010810biological_processregulation of cell-substrate adhesion
D0010811biological_processpositive regulation of cell-substrate adhesion
D0014041biological_processregulation of neuron maturation
D0016020cellular_componentmembrane
D0016358biological_processdendrite development
D0016477biological_processcell migration
D0016601biological_processRac protein signal transduction
D0016787molecular_functionhydrolase activity
D0019899molecular_functionenzyme binding
D0019901molecular_functionprotein kinase binding
D0021799biological_processcerebral cortex radially oriented cell migration
D0021831biological_processembryonic olfactory bulb interneuron precursor migration
D0021894biological_processcerebral cortex GABAergic interneuron development
D0022604biological_processregulation of cell morphogenesis
D0030027cellular_componentlamellipodium
D0030031biological_processcell projection assembly
D0030032biological_processlamellipodium assembly
D0030036biological_processactin cytoskeleton organization
D0030041biological_processactin filament polymerization
D0030334biological_processregulation of cell migration
D0030425cellular_componentdendrite
D0030667cellular_componentsecretory granule membrane
D0030672cellular_componentsynaptic vesicle membrane
D0030742molecular_functionGTP-dependent protein binding
D0030838biological_processpositive regulation of actin filament polymerization
D0030865biological_processcortical cytoskeleton organization
D0030900biological_processforebrain development
D0031116biological_processpositive regulation of microtubule polymerization
D0031410cellular_componentcytoplasmic vesicle
D0031529biological_processruffle organization
D0031901cellular_componentearly endosome membrane
D0031996molecular_functionthioesterase binding
D0032496biological_processresponse to lipopolysaccharide
D0032587cellular_componentruffle membrane
D0032707biological_processnegative regulation of interleukin-23 production
D0032956biological_processregulation of actin cytoskeleton organization
D0034446biological_processsubstrate adhesion-dependent cell spreading
D0035025biological_processpositive regulation of Rho protein signal transduction
D0035556biological_processintracellular signal transduction
D0035567biological_processnon-canonical Wnt signaling pathway
D0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0042470cellular_componentmelanosome
D0042554biological_processsuperoxide anion generation
D0042734cellular_componentpresynaptic membrane
D0042995cellular_componentcell projection
D0043020cellular_componentNADPH oxidase complex
D0043131biological_processerythrocyte enucleation
D0043652biological_processengulfment of apoptotic cell
D0044877molecular_functionprotein-containing complex binding
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0045216biological_processcell-cell junction organization
D0045428biological_processregulation of nitric oxide biosynthetic process
D0045730biological_processrespiratory burst
D0046425biological_processregulation of receptor signaling pathway via JAK-STAT
D0048012biological_processhepatocyte growth factor receptor signaling pathway
D0048168biological_processregulation of neuronal synaptic plasticity
D0048261biological_processnegative regulation of receptor-mediated endocytosis
D0048532biological_processanatomical structure arrangement
D0048812biological_processneuron projection morphogenesis
D0048813biological_processdendrite morphogenesis
D0048870biological_processcell motility
D0048873biological_processhomeostasis of number of cells within a tissue
D0051022molecular_functionRho GDP-dissociation inhibitor binding
D0051492biological_processregulation of stress fiber assembly
D0051496biological_processpositive regulation of stress fiber assembly
D0051668biological_processlocalization within membrane
D0051894biological_processpositive regulation of focal adhesion assembly
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0051932biological_processsynaptic transmission, GABAergic
D0055038cellular_componentrecycling endosome membrane
D0060071biological_processWnt signaling pathway, planar cell polarity pathway
D0060091cellular_componentkinocilium
D0060263biological_processregulation of respiratory burst
D0060326biological_processcell chemotaxis
D0060999biological_processpositive regulation of dendritic spine development
D0061344biological_processregulation of cell adhesion involved in heart morphogenesis
D0070062cellular_componentextracellular exosome
D0070376biological_processregulation of ERK5 cascade
D0071526biological_processsemaphorin-plexin signaling pathway
D0071542biological_processdopaminergic neuron differentiation
D0072659biological_processprotein localization to plasma membrane
D0086098biological_processangiotensin-activated signaling pathway involved in heart process
D0090023biological_processpositive regulation of neutrophil chemotaxis
D0090103biological_processcochlea morphogenesis
D0097178biological_processruffle assembly
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0101003cellular_componentficolin-1-rich granule membrane
D0150052biological_processregulation of postsynapse assembly
D1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
D1900029biological_processpositive regulation of ruffle assembly
D1900242biological_processregulation of synaptic vesicle endocytosis
D1902622biological_processregulation of neutrophil migration
D1903348biological_processpositive regulation of bicellular tight junction assembly
D1904395biological_processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
D1904936biological_processinterneuron migration
D1904948biological_processmidbrain dopaminergic neuron differentiation
D2000386biological_processpositive regulation of ovarian follicle development
D2001222biological_processregulation of neuron migration
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NI A 230
ChainResidue
AHIS211
AHOH2067
AHOH2115
AHOH2117
CHOH2023
CHOH2025
site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG C 202
ChainResidue
CAF3201
CHOH2047
CHOH2224
CTHR17
CTHR35
CGDP200
site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NI C 203
ChainResidue
CHIS103
CHOH2092
site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NI C 204
ChainResidue
CASP76
DASP76
site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG D 202
ChainResidue
DTHR17
DTHR35
DGDP200
DAF3201
DHOH2046
DHOH2224
site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NI D 203
ChainResidue
DHIS103
DHOH2091
DHOH2092
DHOH2093
DHOH2143
site_idAC7
Number of Residues27
DetailsBINDING SITE FOR RESIDUE GDP C 200
ChainResidue
AARG146
ATHR186
ATHR187
AGLY188
AHOH2094
CALA13
CVAL14
CGLY15
CLYS16
CTHR17
CCYS18
CTYR32
CLYS116
CASP118
CLEU119
CSER158
CALA159
CLEU160
CAF3201
CMG202
CHOH2006
CHOH2047
CHOH2224
CHOH2225
CHOH2226
CHOH2227
CHOH2228
site_idAC8
Number of Residues15
DetailsBINDING SITE FOR RESIDUE AF3 C 201
ChainResidue
AARG146
CGLY12
CALA13
CLYS16
CTHR35
CTHR58
CALA59
CGLY60
CGLN61
CGDP200
CMG202
CHOH2026
CHOH2047
CHOH2050
CHOH2224
site_idAC9
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GDP D 200
ChainResidue
BARG146
BTHR186
BTHR187
BGLY188
DALA13
DVAL14
DGLY15
DLYS16
DTHR17
DCYS18
DTYR32
DLYS116
DASP118
DLEU119
DSER158
DALA159
DLEU160
DAF3201
DMG202
DHOH2046
DHOH2221
DHOH2223
DHOH2224
DHOH2225
DHOH2226
site_idBC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE AF3 D 201
ChainResidue
DGLY60
DGLN61
DGDP200
DMG202
DHOH2025
DHOH2046
DHOH2049
DHOH2224
BARG146
DGLY12
DALA13
DLYS16
DTHR35
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI3
Number of Residues16
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WEJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q0N","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"11090627","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WKR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38355798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WEJ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"18093184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23512198","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CGLN61
site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DGLN61
site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
CALA13
site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DALA13

239492

PDB entries from 2025-07-30

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