1FH0
CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR
Summary for 1FH0
Entry DOI | 10.2210/pdb1fh0/pdb |
Related PRD ID | PRD_000325 |
Descriptor | CATHEPSIN V, Nalpha-[(4-methylpiperazin-1-yl)carbonyl]-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-phenylalaninamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | cathepsin, papain, protease, cancer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome : O60911 |
Total number of polymer chains | 2 |
Total formula weight | 49331.48 |
Authors | Somoza, J.R. (deposition date: 2000-07-30, release date: 2001-07-30, Last modification date: 2024-03-13) |
Primary citation | Somoza, J.R.,Zhan, H.,Bowman, K.K.,Yu, L.,Mortara, K.D.,Palmer, J.T.,Clark, J.M.,McGrath, M.E. Crystal structure of human cathepsin V. Biochemistry, 39:12543-12551, 2000 Cited by PubMed: 11027133DOI: 10.1021/bi000951p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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