1FH0
CRYSTAL STRUCTURE OF HUMAN CATHEPSIN V COMPLEXED WITH AN IRREVERSIBLE VINYL SULFONE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CATHEPSIN V | polymer | 221 | 24041.0 | 2 | UniProt (O60911) Pfam (PF00112) | Homo sapiens (human) | CATHEPSIN L2 |
| 2 | C, E (A, B) | Nalpha-[(4-methylpiperazin-1-yl)carbonyl]-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-phenylalaninamide | non-polymer | 576.7 | 2 | BIRD (PRD_000325) Chemie (0IW) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 220 (UniProt: O60911)
| PDB | External Database | Details |
|---|---|---|
| Gln 108 | Asn 221 | engineered mutation |
| Asp 178 | Asn 292 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48081.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1249.6 | |
| All* | Total formula weight | 49331.5 |
