1FGI
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR
Summary for 1FGI
Entry DOI | 10.2210/pdb1fgi/pdb |
Descriptor | FGF RECEPTOR 1, 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE (3 entities in total) |
Functional Keywords | protein kinase, transferase, tyrosine-protein kinase, atp-binding, phosphorylation, inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 71209.87 |
Authors | Mohammadi, M.,Schlessinger, J.,Hubbard, S.R. (deposition date: 1997-03-22, release date: 1998-04-08, Last modification date: 2024-02-07) |
Primary citation | Mohammadi, M.,McMahon, G.,Sun, L.,Tang, C.,Hirth, P.,Yeh, B.K.,Hubbard, S.R.,Schlessinger, J. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science, 276:955-960, 1997 Cited by PubMed: 9139660DOI: 10.1126/science.276.5314.955 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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