1FGI
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | FGF RECEPTOR 1 | polymer | 310 | 35308.6 | 2 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (human) | FGFR1K |
| 2 | C, D (A, B) | 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE | non-polymer | 296.3 | 2 | Chemie (SU1) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 229 | Chemie (HOH) |
Sequence modifications
A, B: 456 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Val 457 | Leu 457 | conflict |
| Ala 488 | Cys 488 | engineered mutation |
| Ser 584 | Cys 584 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70617.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 592.6 | |
| All* | Total formula weight | 71209.9 |
