1EJ9
CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
Summary for 1EJ9
Entry DOI | 10.2210/pdb1ej9/pdb |
Related | 1a31 1a35 1a36 |
Descriptor | DNA (5'-D(*C*AP*AP*AP*AP*AP*GP*AP*CP*TP*CP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'), DNA (5'-D(*C*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*GP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), DNA TOPOISOMERASE I, ... (4 entities in total) |
Functional Keywords | protein-dna complex, type i topoisomerase, human, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleolus: P11387 |
Total number of polymer chains | 3 |
Total formula weight | 80669.03 |
Authors | Redinbo, M.R.,Champoux, J.J.,Hol, W.G. (deposition date: 2000-03-01, release date: 2000-08-03, Last modification date: 2024-02-07) |
Primary citation | Redinbo, M.R.,Champoux, J.J.,Hol, W.G. Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. Biochemistry, 39:6832-6840, 2000 Cited by PubMed: 10841763DOI: 10.1021/bi992690t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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