1EJ9
CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | C | DNA (5'-D(*C*AP*AP*AP*AP*AP*GP*AP*CP*TP*CP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3') | polymer | 23 | 7064.6 | 1 | |||
2 | D | DNA (5'-D(*C*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*GP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3') | polymer | 23 | 7010.6 | 1 | |||
3 | A | DNA TOPOISOMERASE I | polymer | 563 | 66593.8 | 1 | UniProt (P11387) Pfam (PF02919) Pfam (PF01028) Pfam (PF14370) In PDB | Homo sapiens (human) | |
4 | water | water | 18.0 | 353 | Chemie (HOH) |
Sequence modifications
A: 203 - 765 (UniProt: P11387)
PDB | External Database | Details |
---|---|---|
Ile 634 | Arg 634 | engineered mutation |
Phe 723 | Tyr 723 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 80669.0 | |
All* | Total formula weight | 80669.0 |