1EJ9
CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
Functional Information from GO Data
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01382, ECO:0000255|PROSITE-ProRule:PRU10130, ECO:0000269|PubMed:10841763, ECO:0000269|PubMed:12426403, ECO:0000269|PubMed:12533542, ECO:0000269|PubMed:15165849, ECO:0000269|PubMed:15801827, ECO:0000269|PubMed:16033260, ECO:0000269|PubMed:9488644 |
Chain | Residue | Details |
A | PHE723 |
site_id | SWS_FT_FI2 |
Number of Residues | 9 |
Details | SITE: Interaction with DNA |
Chain | Residue | Details |
A | ARG316 | |
A | ARG364 | |
A | TRP412 | |
A | LYS443 | |
A | THR501 | |
A | LYS532 | |
A | ASN574 | |
A | HIS632 | |
A | LYS650 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS280 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:23185622 |
Chain | Residue | Details |
A | SER506 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS204 | |
A | LYS549 | |
A | LYS642 | |
A | LYS700 | |
A | LYS712 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS336 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1k4t |
Chain | Residue | Details |
A | HIS632 | |
A | ARG488 | |
A | ARG590 |