1EAT
NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 5. DESIGN, SYNTHESIS, AND X-RAY CRYSTALLOGRAPHY OF A SERIES OF ORALLY ACTIVE 5-AMINO-PYRIMIDIN-6-ONE-CONTAINING TRIFLUOROMETHYLKETONES
Summary for 1EAT
Entry DOI | 10.2210/pdb1eat/pdb |
Descriptor | PORCINE PANCREATIC ELASTASE, SODIUM ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | hydrolase (serine protease) |
Biological source | Sus scrofa (pig) |
Cellular location | Secreted: P00772 |
Total number of polymer chains | 1 |
Total formula weight | 26632.62 |
Authors | Ceccarelli, C. (deposition date: 1994-11-22, release date: 1995-02-07, Last modification date: 2024-06-05) |
Primary citation | Veale, C.A.,Bernstein, P.R.,Bryant, C.,Ceccarelli, C.,Damewood Jr., J.R.,Earley, R.,Feeney, S.W.,Gomes, B.,Kosmider, B.J.,Steelman, G.B.,Thomas, R.M.,Vacek, E.P.,Williams, J.C.,Wolanin, D.J.,Woolson, S. Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones. J.Med.Chem., 38:98-108, 1995 Cited by PubMed: 7837246DOI: 10.1021/jm00001a015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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