1EAT
NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 5. DESIGN, SYNTHESIS, AND X-RAY CRYSTALLOGRAPHY OF A SERIES OF ORALLY ACTIVE 5-AMINO-PYRIMIDIN-6-ONE-CONTAINING TRIFLUOROMETHYLKETONES
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PORCINE PANCREATIC ELASTASE | polymer | 240 | 25928.0 | 1 | UniProt (P00772) Pfam (PF00089) | Sus scrofa (pig) | |
| 2 | B (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E (A) | 2-[5-METHANESULFONYLAMINO-2-(4-AMINOPHENYL)-6-OXO-1,6-DIHYDRO-1-PYRIMIDINYL]-N-(3,3,3-TRIFLUORO-1-ISOPROPYL-2-OXOPROPYL)ACETAMIDE | non-polymer | 489.5 | 1 | Chemie (TFI) | |||
| 5 | F (A) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A: 16 - 245 (UniProt: P00772)
| PDB | External Database | Details |
|---|---|---|
| Asn 77 | Asp 92 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25928.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 704.6 | |
| All* | Total formula weight | 26632.6 |
