1E9N

A second divalent metal ion in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1, and its implications for the catalytic mechanism

Summary for 1E9N

Entry DOI	10.2210/pdb1e9n/pdb
Related	1BIX 1CQG 1CQH
Descriptor	DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE, LEAD (II) ION (3 entities in total)
Functional Keywords	dna repair, dna repair endonuclease, base excision repair, abasic endonuclease, ape1, hap1, ref-1, alpha, beta sandwich
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	72041.78
Authors	Beernink, P.T.,Segelke, B.W.,Rupp, B. (deposition date: 2000-10-24, release date: 2001-02-16, Last modification date: 2019-05-08)
Primary citation	Beernink, P.T.,Segelke, B.W.,Hadi, M.Z.,Erzberger, J.P.,Wilson III, D.M.,Rupp, B. Two Divalent Metal Ions in the Active Site of a New Crystal Form of Human Apurinic/Apyrimidinic Endonuclease, Ape1: Implications for the Catalytic Mechanism J.Mol.Biol., 307:1023-, 2001 Cited by PubMed: 11286553 DOI: 10.1006/JMBI.2001.4529 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation