1DW6

Structural and kinetic analysis of drug resistant mutants of HIV-1 protease

Summary for 1DW6

• Entry DOI: 10.2210/pdb1dw6/pdb
• Related: 1EBK 1a94 1daz
• Related PRD ID: PRD_000349
• Descriptor: HIV-1 PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total)
• Functional Keywords: hiv-1 protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
• Total number of polymer chains: 2
• Total formula weight: 22350.48

Authors

Mahalingam, B.,Louis, J.M.,Reed, C.C.,Adomat, J.M.,Krouse, J.,Wang, Y.F.,Harrison, R.W.,Weber, I.T. (deposition date: 2000-01-24, release date: 2000-07-26, Last modification date: 2024-02-07)

• Primary citation: Mahalingam, B.,Louis, J.M.,Reed, C.C.,Adomat, J.M.,Krouse, J.,Wang, Y.F.,Harrison, R.W.,Weber, I.T.; Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.; Eur.J.Biochem., 263:238-245, 1999; PubMed: 10429209; DOI: 10.1046/j.1432-1327.1999.00514.x

Experimental method

X-RAY DIFFRACTION (1.88 Å)