1CSB

Crystal structure of cathepsin b inhibited with CA030 at 2.1 angstroms resolution: A basis for the design of specific epoxysuccinyl inhibitors

Summary for 1CSB

• Entry DOI: 10.2210/pdb1csb/pdb
• Related PRD ID: PRD_000310
• Descriptor: CATHEPSIN B light chain, CATHEPSIN B heavy chain, N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-isoleucyl-L-proline, ... (4 entities in total)
• Functional Keywords: papain-like lysosomal dicarboxy-peptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Lysosome: P07858 P07858
• Total number of polymer chains: 4
• Total formula weight: 56048.33

Authors

Turk, D.,Bode, W. (deposition date: 1994-12-09, release date: 1996-04-03, Last modification date: 2012-12-12)

• Primary citation: Turk, D.,Podobnik, M.,Popovic, T.,Katunuma, N.,Bode, W.,Huber, R.,Turk, V.; Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors.; Biochemistry, 34:4791-4797, 1995; PubMed: 7718586; DOI: 10.1021/bi00014a037

Experimental method

X-RAY DIFFRACTION (2 Å)