1CQP

CRYSTAL STRUCTURE ANALYSIS OF THE COMPLEX LFA-1 (CD11A) I-DOMAIN / LOVASTATIN AT 2.6 A RESOLUTION

Summary for 1CQP

Entry DOI	10.2210/pdb1cqp/pdb
Related	1LFA 1ZON 1ZOO 1ZOP
Descriptor	ANTIGEN CD11A (P180), MAGNESIUM ION, LOVASTATIN, ... (4 entities in total)
Functional Keywords	rossmann fold, structural basis for lfa-1 inhibition, immune system
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P20701
Total number of polymer chains	2
Total formula weight	42499.41
Authors	Kallen, J.,Welzenbach, K.,Ramage, P.,Geyl, D.,Kriwacki, R.,Legge, G.,Cottens, S.,Weitz-Schmidt, G.,Hommel, U. (deposition date: 1999-08-10, release date: 2000-08-07, Last modification date: 2024-02-07)
Primary citation	Kallen, J.,Welzenbach, K.,Ramage, P.,Geyl, D.,Kriwacki, R.,Legge, G.,Cottens, S.,Weitz-Schmidt, G.,Hommel, U. Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. J.Mol.Biol., 292:1-9, 1999 Cited by PubMed: 10493852 DOI: 10.1006/jmbi.1999.3047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation