1AUJ
BOVINE TRYPSIN COMPLEXED TO META-CYANO-BENZYLIC INHIBITOR
Summary for 1AUJ
Entry DOI | 10.2210/pdb1auj/pdb |
Descriptor | TRYPSIN, CALCIUM ION, 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID, ... (4 entities in total) |
Functional Keywords | hydrolase, serine proteinase |
Biological source | Bos taurus (cattle) |
Cellular location | Secreted, extracellular space: P00760 |
Total number of polymer chains | 1 |
Total formula weight | 23798.66 |
Authors | Alexander, R.,Smallwood, A.,Kettner, C. (deposition date: 1997-08-28, release date: 1998-10-14, Last modification date: 2024-06-05) |
Primary citation | Lee, S.L.,Alexander, R.S.,Smallwood, A.,Trievel, R.,Mersinger, L.,Weber, P.C.,Kettner, C. New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain. Biochemistry, 36:13180-13186, 1997 Cited by PubMed: 9341205DOI: 10.1021/bi970912m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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