14CQ

Structure of liver pyruvate kinase in complex with allosteric activator 8c

Summary for 14CQ

• Entry DOI: 10.2210/pdb14cq/pdb
• Group deposition: Z-shaped allosteric ligands as activators of liver pyruvate kinase (G_1002372)
• Descriptor: Isoform L-type of Pyruvate kinase PKLR, 1,6-di-O-phosphono-beta-D-fructofuranose, OXALATE ION, ... (7 entities in total)
• Functional Keywords: pyruvate kinase, fluorescence, allosteric site, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 392105.29

Authors

Lulla, A.,Rodriguez Rivero, A.,Grotli, M.,Hyvonen, M. (deposition date: 2026-04-28, release date: 2026-10-14)

• Primary citation: Monjas, L.,Rodriguez-Rivero, A.,Fuchtbauer, A.F.F.,Nilsson, O.,Haversen, L.,Lulla, A.,Brear, P.,Rutberg, M.,Bergh, P.O.,Boren, J.,MARDINOGLU, A.,Hyvonen, M.,Grotli, M.; Symmetry-Guided Fusion Converts Weak Liver Pyruvate Kinase inhibitors into potent Allosteric Activators; Rsc Med Chem, 2026; DOI: 10.1039/D6MD00604C

Experimental method

X-RAY DIFFRACTION (2.184 Å)