14CQ
Structure of liver pyruvate kinase in complex with allosteric activator 8c
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Isoform L-type of Pyruvate kinase PKLR | polymer | 447 | 48285.4 | 8 | UniProt (P30613) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (human) | Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase |
| 2 | AA, FA, I, KA, M... (E, F, A, G, B...) | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 8 | Chemie (FBP) PubChem (10267) | |||
| 3 | BA, GA, J, LA, N... (E, F, A, G, B...) | OXALATE ION | non-polymer | 88.0 | 8 | Chemie (OXL) PubChem (71081) | |||
| 4 | DA, IA, K, MA, O... (E, F, A, G, B...) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) PubChem (888) | |||
| 5 | EA, JA, L, NA, P... (E, F, A, G, B...) | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) PubChem (813) | |||
| 6 | CA, HA, S, X (E, F, C, D) | 5,5'-(naphthalene-2,6-diyldisulfonyl)di(benzene-1,3-diol) | non-polymer | 472.5 | 4 | Chemie (WVT) | |||
| 7 | SA, TA, UA, VA, WA... (A, B, C, D, E...) | water | water | 18.0 | 1432 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 129 (UniProt: P30613)
A, B, C, D, E, F, G, H: 133 - 445 (UniProt: P30613)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Asp 12 | Ser 12 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 130 | - | linker |
| Ser 131 | - | linker |
| Gly 132 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 386283.0 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 5822.3 | |
| All* | Total formula weight | 392105.3 |
