12WW

FGFR3 Kinase Domain with Inhibitor 4-[4-[3-chloro-4-[(1S)-1-(5-fluoro-2-pyridinyl)-2-hydroxyethoxy]pyrazolo[5-a]pyridin-6-yl]-5-methyltriazol-1-yl]piperidine-1-carbonitrile

This is a non-PDB format compatible entry.

Summary for 12WW

• Entry DOI: 10.2210/pdb12ww/pdb
• Descriptor: Fibroblast growth factor receptor 3, (2S)-2-{[(6P,8S)-3-chloro-6-(1-{1-[(Z)-iminomethyl]piperidin-4-yl}-5-methyl-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]oxy}-2-(5-fluoropyridin-2-yl)ethan-1-ol, SULFATE ION, ... (4 entities in total)
• Functional Keywords: fgfr, fgfr3, fibroblast growth factor receptor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35958.36

Authors

Nelson, K.J.,Hoffman, I.D.,Frye, C.B.,Bensen, D.C. (deposition date: 2026-04-21, release date: 2026-10-21)

• Primary citation: Nelson, K.J.,Hoffman, I.D.,Frye, C.B.,Bensen, D.C.; FGFR3 Kinase Domain with Inhibitor 4-[4-[3-chloro-4-[(1S)-1-(5-fluoro-2-pyridinyl)-2-hydroxyethoxy]pyrazolo[5-a]pyridin-6-yl]-5-methyltriazol-1-yl]piperidine-1-carbonitrile; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.04 Å)