12WW
FGFR3 Kinase Domain with Inhibitor 4-[4-[3-chloro-4-[(1S)-1-(5-fluoro-2-pyridinyl)-2-hydroxyethoxy]pyrazolo[5-a]pyridin-6-yl]-5-methyltriazol-1-yl]piperidine-1-carbonitrile
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fibroblast growth factor receptor 3 | polymer | 312 | 35363.4 | 1 | UniProt (P22607) Pfam (PF07714) | Homo sapiens (human) | FGFR-3 |
| 2 | B (A) | (2S)-2-{[(6P,8S)-3-chloro-6-(1-{1-[(Z)-iminomethyl]piperidin-4-yl}-5-methyl-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]oxy}-2-(5-fluoropyridin-2-yl)ethan-1-ol | non-polymer | 498.9 | 1 | Chemie (A1DC5) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A: 448 - 759 (UniProt: P22607)
| PDB | External Database | Details |
|---|---|---|
| Ala 482 | Cys 482 | conflict |
| Glu 650 | Lys 650 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35363.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 595.0 | |
| All* | Total formula weight | 35958.4 |
