12PB

Single particle cryo-EM structure of human MTCH2 (hyperactive mutant K25E Y235A V238D)

Summary for 12PB

• Entry DOI: 10.2210/pdb12pb/pdb
• EMDB information: 76659
• Descriptor: UCP1 Nanobody, Mitochondrial carrier homolog 2,Mitochondrial brown fat uncoupling protein 1 (2 entities in total)
• Functional Keywords: mitochondrial outer membrane insertase, slc25 carrier fold, hydrophilic groove, membrane protein biogenesis, membrane protein
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 47394.53

Authors

Luo, Z.,Stevens, T.A.,Voorhees, R.M. (deposition date: 2026-04-14, release date: 2026-05-13)

• Primary citation: Luo, Z.,Stevens, T.A.,Lee, C.A.,Hazu, M.,Galatis, E.G.,Inglis, A.J.,Guna, A.,Voorhees, R.M.; Structural evolution of the MTCH family of mitochondrial insertases; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.1 Å)