12GT

HDAC1-MTA1 in complex with WNA0 (7-(dimethylamino)-1-(5-(thiophen-2-yl)isoxazol-3-yl)heptan-1-one), a nonhydrolyzable analog of WNA1

This is a non-PDB format compatible entry.

Summary for 12GT

• Entry DOI: 10.2210/pdb12gt/pdb
• Descriptor: Metastasis-associated protein MTA1, Histone deacetylase 1, SULFATE ION, ... (9 entities in total)
• Functional Keywords: hdac1, mta1, wnt inhibitor, nurd, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 78334.38

Authors

Zhou, Z.,Chen, Z. (deposition date: 2026-04-04, release date: 2026-11-11)

• Primary citation: Zhou, Z.,Chen, Z.; A conformation-sensitive product inhibitor of HDAC1/2 potentiates WNT signaling; Nat.Chem.Biol., 2026; DOI: 10.1038/s41589-026-02385

Experimental method

X-RAY DIFFRACTION (2.56 Å)