12DK

structure of human KCNQ1-CaM-PIP2 intermediate state

Summary for 12DK

Entry DOI	10.2210/pdb12dk/pdb
EMDB information	76332
Descriptor	Potassium voltage-gated channel subfamily KQT member 1, Calmodulin-1, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate, ... (4 entities in total)
Functional Keywords	kcnq1, intermediate state, pip2, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	319699.42
Authors	Cui, C.,Kermani, A.,Sun, J. (deposition date: 2026-03-28, release date: 2026-05-06)
Primary citation	Cui, C.,Kermani, A.,Sun, J. PIP2 activation of the cardiac IKs potassium channel To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.47 Å)

Structure validation