12DK
structure of human KCNQ1-CaM-PIP2 intermediate state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, G, H (A, C, E, G) | Potassium voltage-gated channel subfamily KQT member 1 | polymer | 545 | 61945.1 | 4 | UniProt (P51787) Pfam (PF00520) Pfam (PF03520) | Homo sapiens (human) | IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1,KQT-like 1,Voltage-gated potassium channel subunit Kv7.1 |
| 2 | B, C, D, E (B, D, F, H) | Calmodulin-1 | polymer | 149 | 16852.5 | 4 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (human) | |
| 3 | I, R, S, T (A, C, E, G) | [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | non-polymer | 1047.1 | 4 | Chemie (PT5) | |||
| 4 | J, K, L, M, N... (B, D, F, H) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) PubChem (271) |
Sequence modifications
A, C, E, G: 76 - 620 (UniProt: P51787)
| PDB | External Database | Details |
|---|---|---|
| Cys 145 | Ile 145 | engineered mutation |
| Arg 160 | Glu 160 | engineered mutation |
| Glu 231 | Arg 231 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 315190.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4509.0 | |
| All* | Total formula weight | 319699.4 |
