12AP

Cryo-EM structure of alpha-synuclein filaments (singlet) from Parkinson's disease with A53T mutation in SNCA

Summary for 12AP

Entry DOI	10.2210/pdb12ap/pdb
EMDB information	76266
Descriptor	Alpha-synuclein, island B (3 entities in total)
Functional Keywords	alpha-synuclein, protein fibril
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	15290.09
Authors	Zhang, H.,Yang, Y. (deposition date: 2026-03-23, release date: 2026-10-07)
Primary citation	Zhang, H.,Yang, Y. Cryo-EM structure of alpha-synuclein filaments (singlet) from Parkinson's disease with A53T mutation in SNCA To Be Published,
Experimental method	ELECTRON MICROSCOPY (2.1 Å)

Structure validation