12AD

Structure of mammalian Type 2 Inositol 1,4,5-trisphosphate receptors (IP3R2) in the Apo-state

Summary for 12AD

• Entry DOI: 10.2210/pdb12ad/pdb
• EMDB information: 76259 76260
• Descriptor: Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2, ZINC ION, (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL (3 entities in total)
• Functional Keywords: ion channel, membrane protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 4
• Total formula weight: 1247019.28

Authors

Serysheva, I.I.,Baker, M.R.,Fan, G. (deposition date: 2026-03-22, release date: 2026-07-29)

• Primary citation: Baker, M.R.,Lin, X.,Fan, G.,Martinez-Chavez, A.,Wagner, L.E.,Malik, S.,Allison, T.,Bell, B.,Seryshev, A.B.,Cordero-Morales, J.,Baker, M.L.,Yule, D.I.,Serysheva, I.I.; Cryo-EM insights into isoform-specific properties of the IP3R2 channel; Nat Commun, 2026; DOI: 10.1038/s41467-026-75806-y

Experimental method

ELECTRON MICROSCOPY (3.32 Å)