11TV

Crystal structure of alpha/beta-hydrolase macrolide esterase EstX from Escherichia coli (S102A mutant) in complex with linearized tylosin

This is a non-PDB format compatible entry.

Summary for 11TV

• Entry DOI: 10.2210/pdb11tv/pdb
• Descriptor: alpha/beta-hydrolase macrolide esterase EstX, (3~{R},4~{S},5~{S},6~{R},8~{R},10~{E},12~{E},14~{R},15~{R})-14-[[(2~{R},3~{R},4~{R},5~{R},6~{R})-3,4-dimethoxy-6-methyl-5-oxidanyl-oxan-2-yl]oxymethyl]-5-[(2~{R},3~{R},4~{R},5~{S},6~{R})-4-(dimethylamino)-5-[(2~{S},4~{R},5~{S},6~{S})-4,6-dimethyl-4,5-bis(oxidanyl)oxan-2-yl]oxy-6-methyl-3-oxidanyl-oxan-2-yl]oxy-4,8,12-trimethyl-3,15-bis(oxidanyl)-9-oxidanylidene-6-(2-oxidanylideneethyl)heptadeca-10,12-dienoic acid (3 entities in total)
• Functional Keywords: alpha/beta-hydrolase, esterase, macrolide resistance, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 63984.55

Authors

Kelly, E.T.R.,Blanchet, J.,Berghuis, A.M. (deposition date: 2026-03-12, release date: 2026-04-08)

• Primary citation: Kelly, E.T.R.,Myziuk, I.,Hemmings, M.Z.,Mulla, Z.,Blanchet, J.,Ruzzini, A.,Berghuis, A.M.; Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases; Biorxiv, 2026; DOI: 10.64898/2026.03.24.713787

Experimental method

X-RAY DIFFRACTION (1.65 Å)