11TV

Crystal structure of alpha/beta-hydrolase macrolide esterase EstX from Escherichia coli (S102A mutant) in complex with linearized tylosin

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (D, A)	alpha/beta-hydrolase macrolide esterase EstX	polymer	280	31058.2	2	UniProt (Q75WM3)	Escherichia coli	EstX,Putative esterase,Streptothricin acetyl transferase,Streptothricin acetyltransferase
2	C, D (D, A)	(3~{R},4~{S},5~{S},6~{R},8~{R},10~{E},12~{E},14~{R},15~{R})-14-[[(2~{R},3~{R},4~{R},5~{R},6~{R})-3,4-dimethoxy-6-methyl-5-oxidanyl-oxan-2-yl]oxymethyl]-5-[(2~{R},3~{R},4~{R},5~{S},6~{R})-4-(dimethylamino)-5-[(2~{S},4~{R},5~{S},6~{S})-4,6-dimethyl-4,5-bis(oxidanyl)oxan-2-yl]oxy-6-methyl-3-oxidanyl-oxan-2-yl]oxy-4,8,12-trimethyl-3,15-bis(oxidanyl)-9-oxidanylidene-6-(2-oxidanylideneethyl)heptadeca-10,12-dienoic acid	non-polymer		934.1	2	Chemie (A1E2O)
3	E, F (D, A)	water	water		18.0	324	Chemie (HOH)

Sequence modifications

D, A: 1 - 280 (UniProt: Q75WM3)

PDB	External Database	Details
Ala 102	Ser 102	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	62116.3
Non-Polymers*	Number of molecules	2
	Total formula weight	1868.2
All*	Total formula weight	63984.6

*Water molecules are not included.