11GH

Structure of GMPPNP-bound KRAS-G12C/Y96D, a Switch-II Pocket Inhibitor Resistance Mutant, in Complex with the RAF1 RBD-CRD

Summary for 11GH

• Entry DOI: 10.2210/pdb11gh/pdb
• Descriptor: GTPase KRas, RAF proto-oncogene serine/threonine-protein kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
• Functional Keywords: ras, oncogenic mutation, drug resistance, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 35933.56

Authors

Whitley, M.J.,Simanshu, D.K. (deposition date: 2026-02-22, release date: 2026-10-07)

• Primary citation: Whitley, M.J.,Dyba, M.,Chakrabarti, M.,Smith, B.P.,Chan, A.H.,Denson, J.P.,Messing, S.A.,Lin, K.,Cornilescu, G.,Balius, T.E.,Nissley, D.V.,McCormick, F.,Maciag, A.E.,Simanshu, D.K.; Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRAS; Nat Commun, 2026; DOI: 10.1038/s41467-026-78133-4

Experimental method

X-RAY DIFFRACTION (2.5 Å)